Common side effects include jitteriness, headache, and fast heartbeat. Cassano N, Ferrari A, Fai D, et al. (Accessed 21 October 2012). Haller J, Krecsak L, Zámbori J. Double-blind placebo controlled trial of the anxiolytic effects of a standardized Echinacea extract. It might take up to 12 weeks for the echinacea cream to show benefit. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Others at risk for Echinacea side effects include individuals with asthma, auto-immune disorders, HIV or tuberculosis and those on immune-suppressing drugs. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. The Side Effects of Echinacea Tea. A placebo-controlled, randomised, double-blind clinical trial. Phytother.Res 2011;25(4):517-521. Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy--a pilot study. View abstract. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.Clin Pharmacol Ther 2003;73 (Abstract PDII-A-8):P94. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Planta Med 1978;33(1):89-102. Can J Clin Pharmacol 2006;13:e262-7. Evid Based Complement Alternat Med 2012;2012:841315. Ineffectiveness of echinacea for prevention of experimental rhinovirus colds. Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. 2017 Jan;28(1):4-15. Activation of autoimmunity following use of immunostimulatory herbal supplements. View abstract. Echinacea and truth in labeling. View abstract. Dall'Acqua S, Perissutti B, Grabnar I, Farra R, Comar M, Agostinis C, et al. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ECHINACEA. Stevenson JL, Krishnan S, Inigo MM, Stamatikos AD, Gonzales JU, Cooper JA. Echinacea has a long history of being used as an herbal treatment. Press Release: Echinacea herbal products should not be used in children under 12 years old. Parnham MJ. Lee AN, Werth VP. 2015;22(13):1195-200. doi: 10.1016/j.phymed.2015.10.001. 2016;13(3):324-38. doi: 10.3109/19390211.2015.1036189. View abstract. View abstract. Woelkart, K., Marth, E., Suter, A., Schoop, R., Raggam, R. B., Koidl, C., Kleinhappl, B., and Bauer, R. Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system. J Integr Med. Altern Med Rev 2012;17:36-41. Localized reduction of gingival inflammation using site-specific therapy with a topical gingival patch. 2011;146:191-95. View abstract. View abstract. View abstract. Arch Fam Med 1998;7:541-5. 2010;21(11):1045-1059. Although the benefits of echinacea for the common cold are uncertain, the risks seem to be low. Echinacea purpurea for prevention of experimental rhinovirus colds. Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial. Critical hypokalemic renal tubular acidosis due to Sjogren's syndrome: association with the purported immune stimulant echinacea. Int.J Immunopharmacol. Primary information, health benefits, side effects, usage, and other important details What is Echinacea? Echinacea might decrease how quickly the body breaks down caffeine. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Epub 2012 Sep 16. Taking echinacea along with some medications might increase the effects and side effects of some medications. Grimm W, Muller HH. Mistrangelo M, Cornaglia S, Pizzio M, et al. Phytomedicine. Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients. View abstract. View abstract. View abstract. Six weeks of oral Echinacea purpurea supplementation does not enhance the production of serum erythropoietin or erythropoietic status in recreationally active males with above-average aerobic fitness. Appl Physiol Nutr Metab. Side effects The National Institutes of Health (NIH) note that taking Echinacea by mouth for a short time is probably safe, but the effects of long-term use are unclear. 2017 Oct;88(1):67-77. Int.J Dermatol 2009;48:1246-49. Taking echinacea along with caffeine might cause too much caffeine in the bloodstream and increase the risk of side effects. J Clin Pharm Ther 2004;29:75-83. Arch Intern Med 2004;164:1237-41. View abstract. Melchart D, Walther E, Linde K, et al. View abstract. The term 'echinacea' refers to a genera of plants, and a few species in this family including purpurea and angustifolia are desired due to their alkylamide content (seen as … Side Effects & Safety When taken by mouth: Echinacea is LIKELY SAFE for most people when taken by mouth in the short-term. Barrett BP, Brown RL, Locken K, et al. 2015 Nov;97(Pt A):8-14. doi: 10.1016/j.ejpb.2015.09.021. Taking midazolam with echinacea increases how much midazolam the body absorbs. View abstract. There are no known side effects from internal or external use of echinacea. . A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. Common side effects include jitteriness, headache, and fast heartbeat. Dosage of Goldenseal Root. Echinacea Side Effects. View abstract. Recent research suggests that some echinacea supplements may shorten the duration of a cold by about half a day and may slightly reduce symptom severity. diphenhydramine, Benadryl, turmeric, chlorpheniramine, echinacea, saw palmetto, milk thistle, Ginkgo Biloba, Banophen. View abstract. Goel V, Lovlin R, Chang C, et al. Pharmacokinetics and immunomodulatory effect of lipophilic Echinacea extract formulated in softgel capsules. View abstract. J Am Acad Dermatol 2001;44:298-9. Also, make sure you do your research. How Long Does Coronavirus Live On Surfaces? View abstract. In this case, apply Mother tincture to the affected skin after mixing with little quantity of water. Medicinal properties of Echinacea: a critical review. Early research shows that taking 50 drops of a product containing echinacea three times daily for 2 weeks, along with an antibiotic, reduces sore throat and increases overall well-being in people with tonsillitis. This may occur with or without food on the stomach when taking Echinacea. Samuels N, Saffer A, Wexler ID, et al. Phytomedicine 2003;10:66-86. Br J Clin Pharmacol 2013;76(3):467-74. Echinacea is a genus of flowering plants and associated with the Asteraceae family. Wahl RA, Aldous MB, Worden KA, et al. J Altern Complement Med 2005;11:433-9. Moltó J, Valle M, Miranda C, et al. Echinacea for preventing and treating the common cold. Echinacea that is taken long than eight weeks can potentially damage the liver, according to Columbia University's Health Q&A Internet Service. This can result in the sickness not lasting as long. Phytomed 1996;3:95-102. Barrett B. Pharmacotherapy 2010;30(8):797-805. It's not clear if the echinacea cream works as well as steroid or anti-inflammatory eczema creams. Echinacea. South.Med J 2010;103(11):1173-1174. Although not all side effects are known, echinacea is thought to be possibly safe when taken for a short period of time. Schwarz E, Metzler J, Diedrich JP, et al. Medications that decrease the immune system (Immunosuppressants) interacts with ECHINACEA. We comply with the HONcode standard for trustworthy health information -. View abstract. Arzneimittelforschung 2001;51:563-8.. View abstract. 4+ Health Benefits of Echinacea + Side Effects - SelfHacked [Additional treatment with Esberitox N in patients with chemo- radiotherapy treatment of advanced breast cancer]. Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: A randomized, double-blind, placebo-controlled trial. View abstract. When taken by mouth, it can cause nausea, sore throat and numbness and tingling in the mouth. 12-1-2010;47(5):700-705. Biosci.Biotechnol.Biochem. This is not a complete list of side effects and others may occur. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Kemp, D. E. and Franco, K. N. Possible leukopenia associated with long-term use of echinacea. Early research shows that taking an echinacea product daily for 15 days might improve the response to the flu vaccine in people with breathing problems such as bronchitis or asthma. View abstract. The most common side effects of echinacea are digestive tract symptoms, such as nausea or stomach pain. Common side effects may … Compend.Contin.Educ.Dent. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. View abstract. (check all that apply). Tragni E, Tubaro A, Melis S, Galli CL. Those most commonly studied are E. purpurea, E. pallida, and E. Anxiety. 2010;74(7):1350-1354. Samuels N, Grbic JT, Saffer AJ, et al. Learn More. View abstract. Early research shows that applying an echinacea cream (Linola Plus Cream) for 12 weeks can help reduce symptoms of mild eczema such as redness, swelling, itchiness, and dryness compared to using a cream with birch bark. View abstract. J Ocul.Pharmacol Ther 2006;22:431-36. For this reason, liver transplant patients should use extreme caution when using echinacea. But some people can have allergic reactions. Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K. Echinacea for preventing and treating the common cold. Strahlenther.Onkol. Phytomedicine 1996;3:95-102. Information from this source is evidence-based and objective, and without commercial influence. Phytother.Res 2010;24(8):1195-1201. Increased Immunity lowers the chances of getting sick. Saluk-Juszczak, J., Pawlaczyk, I., Olas, B., Kolodziejczyk, J., Ponczek, M., Nowak, P., Tsirigotis-Woloszczak, M., Wachowicz, B., and Gancarz, R. The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins. Did you or will you purchase this product in-store or online? Onkologie. Treatment of the common cold with echinacea: a structured review. View abstract. Gurley BJ, Gardner SF, Hubbard MA, et al. Applying this Homeopathic Mother Tincture directly to the wound can heal within 3 days. J Immunother 2002;25:413-20.. View abstract. Awang DVC, Kindack DG. J Dermatol Sci. 1989;12 Suppl 3:32-8. View abstract. Phytother.Res 2011;25(8):1125-1132. Consumption of echinacea tea is not suggested during pregnancy and breastfeeding or for children below age 12. Eczema (atopic dermatitis). If you want to treat your cold or flu with echinacea, talk to your family doctor first. J Am Board Fam.Pract. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. Muller-Jakic B, Breu W, Probstle A, et al. Some medications are changed and broken down by the liver. View abstract. Call your doctor for medical advice about side effects. View abstract. Taylor JA, Weber W, Standish L, et al. View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. It is an aborigine of eastern and central North America. Early research shows that taking echinacea 150 mg twice daily, in addition to eye drops and a steroid for 4 weeks, doesn't improve vision any more than using only eye drops and steroids in people with this condition. Arch Intern Med 2003;163:699-704. Schroder-Aasen T, Molden G, Nilsen OG. If these effects persist or worsen, tell your doctor. (check all that apply), What factors are most important to you? Am J Med 1999;106:138-43. Pregnancy outcome following gestational exposure to echinacea: A prospective controlled study. von Blumroeder, W. O. Binns SE, Purgina B, Bergeron C. Light-mediated antifungal activity of Echinacea extracts. 2006;81(3):224. View abstract. In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species. Echinacea might decrease how quickly the body breaks down caffeine. Although not all side effects are known, echinacea is thought to be possibly safe when taken for a short period of time. J Paediatr Child Health 2014;50(10):841. Oral supplementation with a nutraceutical containing Echinacea, methionine and antioxidant/immunostimulating compounds in patients with cutaneous viral warts. Severe thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea. T… View abstract. View abstract. Probable etoposide interaction with Echinacea. Phytomedicine 2000;7:273-82. Some medications are changed and broken down by the body. Evaluation of Echinacea for treatment of the common cold. View abstract. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Ann Allergy Asthma Immunol 2008;100:384-8. The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation. Melchart D, Clemm C, Weber B, et al. Am J Hematol. Evidence on the effect of echinacea for the treatment of herpes is unclear. root extract. This article reviews the benefits, uses, side effects and dosage of echinacea. Schulten B, Bulitta M, Ballering-Bruhl B, et al. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. View abstract. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Int J STD AIDS. Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation. 2019;44(7):791-795. BMC.Complement Altern.Med 2008;8:56. Ear infection (otitis media). Sign Up to Receive Our Free Coroanvirus Newsletter, 13 Natural Ways to Help Little Ones Feel Better. Common cold. Echinacea root extracts for the prevention of upper respiratory tract infections: a double-blind, placebo-controlled randomized trial. Cochrane Database Syst Rev 2006;(1):CD000530. ZFA.(Stuttgart.) Allergic reactions to Echinacea. View abstract. A combination with prescribed medication must also be taken into consideration. Barrett B, Brown R, Rakel D, Rabago D, et al. Colorectal Dis 2010;12:799-803. View abstract. Echinacea for treating the common cold: a randomized trial. Caruso TJ, Gwaltney JM Jr. Abdul MI, Jiang X, Williams KM, et al. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. View abstract. The effect of Echinacea purpurea on the pharmacokinetics of docetaxel. Nausea, numbness/tingling of the lips/tongue, and an unpleasant taste in the mouth may occur. View abstract. Recurrent erythema nodosum associated with echinacea herbal therapy. Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others. View abstract. Drug Saf 2005;28:387-400. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. Thompson, K. D. Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Evidence from two classic irritation tests for an anti-inflammatory action of a natural extract, Echinacina B. View abstract. Genital herpes. View abstract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Kocaman O, Hulagu S, Senturk O. Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis. Maybe, but not by much. Use of echinacea for the treatment of anxiety and cancer has been investigated. In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. J Assist Reprod Genet 1999;16:87-91. Functions as a Laxative. Goel V, Lovlin R, Barton R, et al. 28 November, 2018 . Echinacea might change how the body breaks down some medications. View abstract. When taking the two together, you should know if the side effects outweigh the goldenseal and echinacea benefits. Gorski JC, Huang S, Zaheer NA, et al. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. J Clin Pharmacol 2005;45(6):683-689. Attention deficit-hyperactivity disorder (ADHD). Phytother.Res. Lancet Infect Dis 2007;7:473-80. Nausea, numbness/tingling of the lips/tongue, and an unpleasant taste in the mouth may occur. Luettig B, Steinmuller C, Gifford GE, et al. View abstract. Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt. Efficacy of Echinacea purpurea in patients with a common cold. View abstract. View abstract. Swelling (inflammation) of the eye (uveitis). Some side effects may not be reported. It has been used as a traditional herbal remedy since the 18th century for a range of conditions from pain relief to snake bites, and even anthrax infections.1,2 Nowadays, echinacea is commonly used to reliev… Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. View abstract. Echinacea, also known as American coneflower, is a wild herb that grows in the plains of North America. J.Clin.Dent. JAMA 2003;290:2824-30.. View abstract. J Postgrad Med. View abstract. View abstract. Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold. Giles JT, Palat CT III, Chien SH, et al. View abstract. A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold. American Indians were known to have used the treatment for a wide range of ailments before western settlers began using it in the 1800s. Infect Immun 1984;46:845-9. Oláh A, Szabó-Papp J, Soeberdt M, et al. Running economy and maximal oxygen consumption after 4 weeks of oral Echinacea supplementation. 2015;20;77:66-72. doi: 10.1016/j.curtheres.2015.04.001. Whitehead MT, Martin TD, Scheett TP, et al. Brinkeborn RM, Shah DV, Degenring FH. Planta Med 1995;61:510-4. Some research shows that taking an echinacea extract twice daily for 6 months does not seem to prevent genital herpes or make them less frequent or severe. It may even reduce the effects of Immunosuppressive drugs. Some children participating in a clinical trial of echinacea developed rashes, which may … View abstract. View abstract. Schoop R, Klein P, Suter A, Johnston SL. A. Echinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjects. Chavez ML, Chavez PI. Oral Echinacea purpurea extract in low-grade, steroid-dependent, autoimmune idiopathic uveitis: a pilot study. View abstract. Clin Infect Dis 2005;40:807-10. Logan JL, Ahmed J. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Treatment of the common cold with unrefined echinacea. Eur J Pharm Biopharm. Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of echinacea extracts in the prevention of skin photodamage. Z Allg Med 1985;61:271-273. Although not all side effects are known, echinacea is thought to be possibly safe when taken for a short period of time. View abstract. Because it has a long history of use, researchers have been studying the herb for decades with mixed results. American Cone Flower, Black Sampson, Black Susans, Brauneria Angustifolia, Brauneria Pallida, Brauneria Purpurea, Comb Flower, Coneflower, Echinacea Angustifolia, Echinacea Pallida, Echinacea Purpurea, Echinacea Serotine, Echinacea Speciose, Echinaceawurzel, Échinacée, Échinacée Angustifolia, Échinacée Pallida, Échinacée Pourpre, Échinacée Purpurea, Equinácea, Fleur À Hérisson, Hedgehog, Helichroa Purpurea, Igelkopfwurzel, Indian Head, Kansas Snakeroot, Narrow-Leaved Echinacea, Narrow-Leaved Purple Coneflower, Narrow-Leaved Purple Cone Flower, Pale Coneflower, Pale Flower Echinacea, Pale Purple Coneflower, Purple Coneflower, Purple Cone Flower, Purpursonnenhutkraut, Purpursonnenhutwurzel, Racine D'echininacea, Red Sunflower, Rock-Up-Hat, Roter Sonnenhut, Rudbeckia Purpurea, Rudbeckie Pourpre, Schmallblaettrige Kegelblumenwurzel, Schmallblaettriger Sonnenhut, Scurvy Root, Snakeroot, Sonnenhutwurzel. It is commonly known as American Coneflower. Grbic J, Wexler I, Celenti R, et al. 2011;142:1168-75. Early research shows that taking a specific liquid echinacea extract three times daily for 3 days at the first sign of a common cold does not prevent an ear infection in children 1-5 years-old with a history of ear infections. Linde K, Barrett B, Wolkart K, et al. A randomized, double-blind, placebo-controlled trial. There are at least 9 species of echinacea. Acute, subacute and genotoxicity studies. This helps the body do a better job fighting the infection. It is always good to discuss with your doctor on the usage and dosage of echinacea if you have any pre-existing health issues. Echinagard treatment shortens the course of the common cold: a double blind, placebo-controlled clinical trial. How Much Do You Know About Adult Whooping Cough? Eur J Clin Res 1997;9:261-268. 2010;69:508-15. nausea, vomiting, stomach pain, diarrhea; unusual or unpleasant taste in the mouth; Echinacea applied to the skin in a topical form can cause an itchy or red skin rash. 11-20-1982;58:1795-98. A sexually transmitted infection that can lead to genital warts or cancer (human papillomavirus or HPV). View abstract. View abstract. Effects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebo-controlled trial. Phytother Res 2002;16:138-42.. View abstract. 2015;313(6):618-9. doi: 10.1001/jama.2014.17145. View abstract. They multiply the activity of the immune system and increase white blood cells. Echinacea-induced acute liver failure in a child. Ondrizek RR, Chan PJ, Patton WC, King A. Ondrizek RR, Chan PJ, Patton WC, King A. Inhibition of human sperm motility by specific herbs used in alternative medicine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Shah SA, Sander S, White CM, et al. If these effects persist or worsen, tell your doctor. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Vonau B, Chard S, Mandalia S, et al. Taking echinacea along with some medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system. But the benefit is probably small. Call your doctor for medical advice about side effects. View abstract. Taking echinacea by mouth while still healthy may help prevent colds. View abstract. Early research shows that taking echinacea four times daily for 28 days increases oxygen intake during exercise tests in healthy men. Like many herbs, echinacea is particularly healing for the stomach and … Bockhorst H, Gollnick N, Guran S, et al. Some medications changed by the body include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and many others. Some people have allergic reactions to echinacea, which may be severe. Bensch, K., Tiralongo, J., Schmidt, K., Matthias, A., Bone, K. M., Lehmann, R., and Tiralongo, E. Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni. Bresesti I, Ricci M, Cerritelli F, Veneziano A, Zuccotti G, Lista G. Comparison between two ocular cleansing modalities in a population of newborns admitted to Neonatal Intensive Care Unit with clinical signs of conjunctivitis: a randomized controlled trial. August 20, 2012. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Huntley AL, Thompson Coon J, Ernst E. The safety of herbal medicinal products derived from Echinacea species: a systematic review. While echinacea and goldenseal can be most beneficial together, they do come with their own side effects. Ann Intern Med 2010;153:769-77. Pharmacother 2000;20:690-7. Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. Food Chem Toxicol 1985;23:317-9.. View abstract. View abstract. Gallo M, Sarkar M, Au W, et al. View abstract. Flu (influenza). Echinacea enhances the Immune system. They believe it stimulates the immune system. Whether this is good or bad isn't yet known. View abstract. Phytother Res, 2020;34(3):660-8. View abstract. Bendel R, Bendel V, Renner K, et al. Ear infections actually seemed to increase. The warnings about negative effects of echinacea use in people with immune disorders are based on laboratory studies. Antimicrob Agents Chemother 2000;44:1708-9. Phytother.Res 2005;19:689-94. View abstract. You may report them to the FDA. Int J Clin Pharmacol Ther 2006;44(9):401-408. J Am Dent.Assoc. Taking echinacea after catching a cold doesn't seem to have much benefit. Perry NB, van Klink JW, Burgess EJ, et al. [Therapy of herpes simplex in practice. Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Yale SH, Liu K. Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial. J Fam Pract 1999;48:628-35. View abstract. Di Pierro F, Rapacioli G, Ferrara T, Togni S. Use of a standardized extract from Echinacea angustifolia (Polinacea) for the prevention of respiratory tract infections. Alkamide levels in Echinacea purpurea: effects of processing, drying and storage. Facino RM, Carini M, Aldini G, et al. Quiz: What Do You Know About Vitamin B12 Deficiency? Damages Liver. Planta Med 1994;60:37-40.. View abstract. This survey is being conducted by the WebMD marketing sciences department. Toselli, F., Matthias, A., Bone, K. M., Gillam, E. M., and Lehmann, R. P. Metabolism of the major Echinacea alkylamide N-isobutyldodeca-2E,4E,8Z,10Z-tetraenamide by human recombinant cytochrome P450 enzymes and human liver microsomes.